Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
Identifieur interne : 006F89 ( Main/Exploration ); précédent : 006F88; suivant : 006F90Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
Auteurs : Karine Labadie [France] ; Thibaut Larcher [France] ; Christophe Joubert [France] ; Abdelkrim Mannioui [France] ; Benoit Delache [France] ; Patricia Brochard [France] ; Lydie Guigand [France] ; Laurence Dubreil [France] ; Pierre Lebon [France] ; Bernard Verrier [France] ; Xavier De Lamballerie [France] ; Andreas Suhrbier [Australie] ; Yan Cherel [France] ; Roger Le Grand [France] ; Pierre Roques [France]Source :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2010.
Abstract
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints. The recent emergence or reemergence of CHIKV in the Indian Ocean Islands and India has stressed the need to better understand the pathogenesis of this disease. Previous CHIKV disease models have used young or immunodeficient mice, but these do not recapitulate human disease patterns and are unsuitable for testing immune-based therapies. Herein, we describe what we believe to be a new model for CHIKV infection in adult, immunocompetent cynomolgus macaques. CHIKV infection in these animals recapitulated the viral, clinical, and pathological features observed in human disease. In the macaques, long-term CHIKV infection was observed in joints, muscles, lymphoid organs, and liver, which could explain the long-lasting CHIKV disease symptoms observed in humans. In addition, the study identified macrophages as the main cellular reservoirs during the late stages of CHIKV infection in vivo. This model of CHIKV physiopathology should allow the development of new therapeutic and/or prophylactic strategies.
Url:
DOI: 10.1172/JCI40104
PubMed: 20179353
PubMed Central: 2827953
Affiliations:
- Australie, France
- Auvergne-Rhône-Alpes, Pays de la Loire, Provence-Alpes-Côte d'Azur, Rhône-Alpes, Île-de-France
- Lyon, Marseille, Nantes, Orsay, Paris
- Université de la Méditerranée
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Le document en format XML
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<placeName><settlement type="city">Orsay</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guigand, Lydie" sort="Guigand, Lydie" uniqKey="Guigand L" first="Lydie" last="Guigand">Lydie Guigand</name>
<affiliation wicri:level="3"><nlm:aff id="JCI40104">INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dubreil, Laurence" sort="Dubreil, Laurence" uniqKey="Dubreil L" first="Laurence" last="Dubreil">Laurence Dubreil</name>
<affiliation wicri:level="3"><nlm:aff id="JCI40104">INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lebon, Pierre" sort="Lebon, Pierre" uniqKey="Lebon P" first="Pierre" last="Lebon">Pierre Lebon</name>
<affiliation wicri:level="3"><nlm:aff id="JCI40104">Université Paris V, Hôpital Cochin-St Vincent de Paul, Service de virologie, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Université Paris V, Hôpital Cochin-St Vincent de Paul, Service de virologie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Verrier, Bernard" sort="Verrier, Bernard" uniqKey="Verrier B" first="Bernard" last="Verrier">Bernard Verrier</name>
<affiliation wicri:level="3"><nlm:aff id="JCI40104">CNRS, UMR 5086, IBCP-IFR 128, Lyon, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>CNRS, UMR 5086, IBCP-IFR 128, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Lamballerie, Xavier" sort="De Lamballerie, Xavier" uniqKey="De Lamballerie X" first="Xavier" last="De Lamballerie">Xavier De Lamballerie</name>
<affiliation wicri:level="4"><nlm:aff id="JCI40104">Université de la Méditerranée, Unité des Virus Emergents, Marseille, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Université de la Méditerranée, Unité des Virus Emergents, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université de la Méditerranée</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="JCI40104">Institut de Recherche pour le Développement, Marseille, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name>
<affiliation wicri:level="1"><nlm:aff id="JCI40104">Australian Centre for International and Tropical Health, Queensland Institute of Medical Research, Brisbane, Australia.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea>Australian Centre for International and Tropical Health, Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cherel, Yan" sort="Cherel, Yan" uniqKey="Cherel Y" first="Yan" last="Cherel">Yan Cherel</name>
<affiliation wicri:level="3"><nlm:aff id="JCI40104">INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Grand, Roger" sort="Le Grand, Roger" uniqKey="Le Grand R" first="Roger" last="Le Grand">Roger Le Grand</name>
<affiliation wicri:level="1"><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses</wicri:regionArea>
<wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion>
<wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>UMR-E1, Paris-Sud 11, Orsay</wicri:regionArea>
<placeName><settlement type="city">Orsay</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roques, Pierre" sort="Roques, Pierre" uniqKey="Roques P" first="Pierre" last="Roques">Pierre Roques</name>
<affiliation wicri:level="1"><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses</wicri:regionArea>
<wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion>
<wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>UMR-E1, Paris-Sud 11, Orsay</wicri:regionArea>
<placeName><settlement type="city">Orsay</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Clinical Investigation</title>
<idno type="ISSN">0021-9738</idno>
<idno type="eISSN">1558-8238</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints. The recent emergence or reemergence of CHIKV in the Indian Ocean Islands and India has stressed the need to better understand the pathogenesis of this disease. Previous CHIKV disease models have used young or immunodeficient mice, but these do not recapitulate human disease patterns and are unsuitable for testing immune-based therapies. Herein, we describe what we believe to be a new model for CHIKV infection in adult, immunocompetent cynomolgus macaques. CHIKV infection in these animals recapitulated the viral, clinical, and pathological features observed in human disease. In the macaques, long-term CHIKV infection was observed in joints, muscles, lymphoid organs, and liver, which could explain the long-lasting CHIKV disease symptoms observed in humans. In addition, the study identified macrophages as the main cellular reservoirs during the late stages of CHIKV infection in vivo. This model of CHIKV physiopathology should allow the development of new therapeutic and/or prophylactic strategies.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Pays de la Loire</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhône-Alpes</li>
<li>Île-de-France</li>
</region>
<settlement><li>Lyon</li>
<li>Marseille</li>
<li>Nantes</li>
<li>Orsay</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de la Méditerranée</li>
</orgName>
</list>
<tree><country name="France"><noRegion><name sortKey="Labadie, Karine" sort="Labadie, Karine" uniqKey="Labadie K" first="Karine" last="Labadie">Karine Labadie</name>
</noRegion>
<name sortKey="Brochard, Patricia" sort="Brochard, Patricia" uniqKey="Brochard P" first="Patricia" last="Brochard">Patricia Brochard</name>
<name sortKey="Brochard, Patricia" sort="Brochard, Patricia" uniqKey="Brochard P" first="Patricia" last="Brochard">Patricia Brochard</name>
<name sortKey="Cherel, Yan" sort="Cherel, Yan" uniqKey="Cherel Y" first="Yan" last="Cherel">Yan Cherel</name>
<name sortKey="De Lamballerie, Xavier" sort="De Lamballerie, Xavier" uniqKey="De Lamballerie X" first="Xavier" last="De Lamballerie">Xavier De Lamballerie</name>
<name sortKey="De Lamballerie, Xavier" sort="De Lamballerie, Xavier" uniqKey="De Lamballerie X" first="Xavier" last="De Lamballerie">Xavier De Lamballerie</name>
<name sortKey="Delache, Benoit" sort="Delache, Benoit" uniqKey="Delache B" first="Benoit" last="Delache">Benoit Delache</name>
<name sortKey="Delache, Benoit" sort="Delache, Benoit" uniqKey="Delache B" first="Benoit" last="Delache">Benoit Delache</name>
<name sortKey="Dubreil, Laurence" sort="Dubreil, Laurence" uniqKey="Dubreil L" first="Laurence" last="Dubreil">Laurence Dubreil</name>
<name sortKey="Guigand, Lydie" sort="Guigand, Lydie" uniqKey="Guigand L" first="Lydie" last="Guigand">Lydie Guigand</name>
<name sortKey="Joubert, Christophe" sort="Joubert, Christophe" uniqKey="Joubert C" first="Christophe" last="Joubert">Christophe Joubert</name>
<name sortKey="Joubert, Christophe" sort="Joubert, Christophe" uniqKey="Joubert C" first="Christophe" last="Joubert">Christophe Joubert</name>
<name sortKey="Labadie, Karine" sort="Labadie, Karine" uniqKey="Labadie K" first="Karine" last="Labadie">Karine Labadie</name>
<name sortKey="Larcher, Thibaut" sort="Larcher, Thibaut" uniqKey="Larcher T" first="Thibaut" last="Larcher">Thibaut Larcher</name>
<name sortKey="Le Grand, Roger" sort="Le Grand, Roger" uniqKey="Le Grand R" first="Roger" last="Le Grand">Roger Le Grand</name>
<name sortKey="Le Grand, Roger" sort="Le Grand, Roger" uniqKey="Le Grand R" first="Roger" last="Le Grand">Roger Le Grand</name>
<name sortKey="Lebon, Pierre" sort="Lebon, Pierre" uniqKey="Lebon P" first="Pierre" last="Lebon">Pierre Lebon</name>
<name sortKey="Mannioui, Abdelkrim" sort="Mannioui, Abdelkrim" uniqKey="Mannioui A" first="Abdelkrim" last="Mannioui">Abdelkrim Mannioui</name>
<name sortKey="Mannioui, Abdelkrim" sort="Mannioui, Abdelkrim" uniqKey="Mannioui A" first="Abdelkrim" last="Mannioui">Abdelkrim Mannioui</name>
<name sortKey="Roques, Pierre" sort="Roques, Pierre" uniqKey="Roques P" first="Pierre" last="Roques">Pierre Roques</name>
<name sortKey="Roques, Pierre" sort="Roques, Pierre" uniqKey="Roques P" first="Pierre" last="Roques">Pierre Roques</name>
<name sortKey="Verrier, Bernard" sort="Verrier, Bernard" uniqKey="Verrier B" first="Bernard" last="Verrier">Bernard Verrier</name>
</country>
<country name="Australie"><noRegion><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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